More than one goal to qualify, top 20 shown.
| Player (team) |
Goals |
Minutes played |
Minutes/goal |
| Gonzalo Castro (Mallorca) |
5 |
420 |
84.0 |
| Diego Forlan (Atletico Madrid) |
32 |
3119 |
97.5 |
| Alhassane Keita (Mallorca) |
5 |
503 |
100.6 |
| Samuel Eto'o (Barcelona) |
35 |
3696 |
105.6 |
| Leo Messi (Barcelona) |
29 |
3094 |
106.7 |
| David Villa (Valencia) |
27 |
2959 |
109.6 |
| Ernesto Javier Chevanton (Sevilla) |
3 |
331 |
110.3 |
| Ruud van Nistelrooy (Real Madrid) |
7 |
819 |
117.0 |
| Thierry Henry (Barcelona) |
22 |
2811 |
127.8 |
| Gonzalo Higuain (Real Madrid) |
22 |
2929 |
133.1 |
| Klaas-Jan Huntelaar (Real Madrid) |
8 |
1125 |
140.6 |
| Frederic Kanoute (Sevilla) |
19 |
2682 |
141.2 |
| Nikola Zigic (Racing Santander) |
11 |
1602 |
145.6 |
| Joseba Llorente (Villarreal) |
18 |
2628 |
146.0 |
| Sergio Aguero (Atletico Madrid) |
21 |
3237 |
154.1 |
| Gonzalez Raul (Real Madrid) |
21 |
3421 |
162.9 |
| Walter Pandiani (Osasuna) |
11 |
1828 |
166.2 |
| Ballesta Salva (Malaga) |
3 |
505 |
168.3 |
| Rodriguez Vicente (Valencia) |
5 |
882 |
176.4 |
| Giuseppe Rossi (Villarreal) |
14 |
2636 |
188.3 |
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